Gas1 Gene Summary [Mouse]
Enables oxysterol binding activity. Involved in several processes, including negative regulation of cell growth; odontogenesis; and regulation of smoothened signaling pathway. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of smoothened signaling pathway. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human GAS1 (growth arrest specific 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gas1 |
| Official Name | growth arrest specific 1 [Source:MGI Symbol;Acc:MGI:95655] |
| Ensembl ID | ENSMUSG00000052957 |
| Bio databases IDs | |
| Aliases | growth arrest specific 1 |
| Synonyms | growth arrest-specific 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- N-linked glycosylation site
- protein binding
- GDNF/GAS1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- synostosis
- microform holoprosencephaly
- brachyphalangia
- non-insulin-dependent diabetes mellitus
- uterine serous papillary cancer
- cleft palate
- lung adenocarcinoma
- lung adenocarcinoma formation
- borderline personality disorder
role in cell
- upregulation in
- apoptosis
- expression in
- proliferation
- growth
- cell cycle progression
- S phase
- cisplatin resistance
- abnormal morphology
- 5-fluorouracil resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ER to Golgi vesicle-mediated transport
- negative regulation of protein processing
- cell fate commitment
- negative regulation of mitotic cell cycle
- regulation of apoptotic process
- cellular response to vascular endothelial growth factor stimulus
- developmental growth
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxysterol binding