NFIL3 Gene Summary [Human]
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | NFIL3 |
| Official Name | nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] |
| Ensembl ID | ENSG00000165030 |
| Bio databases IDs | |
| Aliases | nuclear factor, interleukin 3 regulated, E4 promoter-binding protein, adenovirus E4 promoter region binding protein |
| Synonyms | E4BP4, IL3BP1, NF-IL3A, NUCLEAR FACTOR, INTERLEUKIN 3 REGULATED, nuclear factor, interleukin 3, regulated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFIL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Vertebrate interleukin-3 regulated transcription factor
- double-stranded DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the NFIL3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- breast cancer
- rectal prolapse
- experimental autoimmune encephalomyelitis
- weight loss
- diarrhea
- amyotrophic lateral sclerosis
- colitis
- androgenic alopecia
- endometriosis
role in cell
- survival
- expression in
- production in
- degradation in
- cell viability
- apoptosis
- cell death
- number
- activation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFIL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- immune response
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- natural killer cell differentiation
- cellular response to interleukin-4
- transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- circadian rhythm
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity