MAPK15 Gene Summary [Human]
Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | MAPK15 |
| Official Name | mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667] |
| Ensembl ID | ENSG00000181085 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 15, extracellular signal regulated kinase 8 |
| Synonyms | BC048082, ERK7, ERK-8, mitogen-activated protein kinase 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAPK15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- MAP kinase
- chromatin binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAPK15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- neoplastic cell transformation
- progression free survival
role in cell
- expression in
- growth
- phosphorylation in
- proliferation
- binding in
- migration
- assembly
- survival
- autophagy in
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- basal bodies
- Golgi Apparatus
- centriole
- intercellular junctions
- autophagic vacuoles
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAPK15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- MAPK cascade
- positive regulation of cell proliferation
- regulation of autophagy
- positive regulation of telomere maintenance via telomerase
- protein autophosphorylation
- response to DNA damage stimulus
- endoplasmic reticulum organization
- intracellular signal transduction
- negative regulation of cell migration
- regulation of COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- Golgi apparatus
- extracellular region
- axoneme
- autophagic vacuole
- nucleus
- tight junction
- cell-cell junction
- cytoplasm
- centriole
- cytoplasmic vesicle
- meiotic spindle
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- MAP kinase activity
- protein kinase activity
- chromatin binding
- SH3 domain binding
- protein serine/threonine kinase activity
- kinase activity