F2RL2 Gene Summary [Human]
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | F2RL2 |
| Official Name | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] |
| Ensembl ID | ENSG00000164220 |
| Bio databases IDs | |
| Aliases | coagulation factor II thrombin receptor like 2, proteinase-activated receptor-3 |
| Synonyms | coagulation factor II (thrombin) receptor-like 2, coagulation factor II thrombin receptor like 2, F730031A08, PAR-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human F2RL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- conserved domain
- extracellular domain
- thrombin receptor
- 7 transmembrane receptor (rhodopsin family)
- receptor agonist activity
- protein binding
- cleavage site
- seven-transmembrane G protein-coupled receptor superfamily
- proteinase activated receptor
Pathways
Biological processes and signaling networks where the F2RL2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- Hutchinson-Gilford progeria syndrome
- ischemic injury
- embolism
- colorectal cancer
- thrombosis
- early missed abortion
- pruritus
- bleeding
role in cell
- signaling in
- phosphorylation in
- activation in
- formation
- formation in
- activation
- function
- neuroprotection
- mobilization in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human F2RL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thrombin receptor signaling pathway
- positive regulation of Rho protein signal transduction
- response to wounding
- positive regulation of insulin secretion
- phospholipase C-activating G-protein coupled receptor signaling pathway
- blood coagulation
- platelet activation
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
- extracellular region
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- phosphatidylinositol phospholipase C activity
- protein binding
- thrombin receptor activity
- receptor agonist activity