FBXL6 Gene Summary [Human]
This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Retained Intron |
| Official Symbol | FBXL6 |
| Official Name | F-box and leucine rich repeat protein 6 [Source:HGNC Symbol;Acc:HGNC:13603] |
| Ensembl ID | ENSG00000182325 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 6 |
| Synonyms | FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, PP14630 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- activation in
- expression in
- migration
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity