ADI1 Gene Summary [Human]
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | ADI1 |
| Official Name | acireductone dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:30576] |
| Ensembl ID | ENSG00000182551 |
| Bio databases IDs | |
| Aliases | acireductone dioxygenase 1, membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 |
| Synonyms | acireductone dioxygenase 1, ALP1, APL1, ARD, ARD', Fe-ARD, HMFT1638, MTCBP-1, Mtnd, Ni-ARD, SIPL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- enzyme
- protein binding
- acireductone dioxygenase (Ni2+-requiring)
- RmlC-like cupin superfamily
- ARD/ARD' family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- invadopodia
- cell periphery
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-methionine salvage from methylthioadenosine
- methionine metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- iron ion binding
- nickel cation binding
- acireductone dioxygenase [iron(II)-requiring] activity
- acireductone dioxygenase (Ni2+-requiring) activity