Adi1 Gene Summary [Mouse]
Predicted to enable acireductone dioxygenase [iron(II)-requiring] activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; respiratory system; and sensory organ. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adi1 |
| Official Name | acireductone dioxygenase 1 [Source:MGI Symbol;Acc:MGI:2144929] |
| Ensembl ID | ENSMUSG00000020629 |
| Bio databases IDs | |
| Aliases | acireductone dioxygenase 1 |
| Synonyms | acireductone dioxygenase 1, ALP1, APL1, ARD, ARD', Fe-ARD, HMFT1638, MTCBP-1, Mtnd, Ni-ARD, SIPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- enzyme
- protein binding
- acireductone dioxygenase (Ni2+-requiring)
- RmlC-like cupin superfamily
- ARD/ARD' family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- invadopodia
- cell periphery
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-methionine salvage from methylthioadenosine
- methionine metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- iron ion binding
- nickel cation binding
- acireductone dioxygenase [iron(II)-requiring] activity
- acireductone dioxygenase (Ni2+-requiring) activity