GAS6 Gene Summary [Human]
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Details
| Type | Retained Intron |
| Official Symbol | GAS6 |
| Official Name | growth arrest specific 6 [Source:HGNC Symbol;Acc:HGNC:4168] |
| Ensembl ID | ENSG00000183087 |
| Bio databases IDs | |
| Aliases | growth arrest specific 6, AXL stimulatory factor |
| Synonyms | AXLLG, AXSF, GROWTH ARREST-SPECIFIC, growth arrest specific 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAS6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Complement Clr-like EGF-like
- LamG
- protein binding activity, bridging
- caspase inhibitor activity
- protein binding
- receptor binding
- growth factor
- EGF_CA
- laminin-like globular domain
- binding protein
- receptor tyrosine kinase binding
- EGF domain
- receptor agonist activity
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- laminin G domain
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- infection
- diabetes mellitus
- dilated cardiomyopathy
- endothelial dysfunction
- obesity
- major depression
- diabetic nephropathy
- sepsis
- endometriosis
role in cell
- proliferation
- expression in
- apoptosis
- cell death
- production in
- growth
- activation in
- differentiation
- phosphorylation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- alpha granules
- photoreceptor inner segments
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAS6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-1 production
- extracellular matrix assembly
- virion attachment, binding of host cell surface receptor
- negative regulation of transcription, DNA-dependent
- cellular response to glucose stimulus
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of dendritic cell chemotaxis
- negative regulation of biomineral tissue development
- negative regulation of endothelial cell apoptotic process
- negative regulation of interferon-gamma production
- positive regulation of TOR signaling cascade
- B cell chemotaxis
- negative regulation of tumor necrosis factor production
- positive regulation of protein export from nucleus
- negative regulation of oligodendrocyte apoptotic process
- apoptotic cell clearance
- negative regulation of interleukin-6 production
- positive regulation of protein kinase activity
- cellular response to growth factor stimulus
- positive regulation of gene expression
- viral genome replication
- organ regeneration
- positive regulation of phagocytosis
- cell-substrate adhesion
- protein localization in plasma membrane
- positive regulation of protein kinase B signaling cascade
- viral entry into host cell
- blood coagulation
- protein phosphorylation
- positive regulation of glomerular filtration
- positive regulation of natural killer cell differentiation
- positive regulation of cytokine-mediated signaling pathway
- neuron migration
- viral envelope fusion with host membrane
- positive regulation of fibroblast proliferation
- dendritic cell differentiation
- calcium ion transmembrane transport
- negative regulation of renal albumin absorption
- cellular response to interferon-alpha
- activation of protein kinase B activity
- negative regulation of fibroblast apoptotic process
- negative regulation of myeloid cell apoptotic process
- signal transduction
- fibroblast apoptotic process
- cell surface receptor signaling pathway
- enzyme linked receptor protein signaling pathway
- cellular response to starvation
- hematopoietic stem cell migration to bone marrow
- negative regulation of dendritic cell apoptotic process
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- phagocytosis
- cellular response to xenobiotic stimulus
- cellular response to vitamin K
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- calcium ion binding
- receptor agonist activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- protein binding, bridging
- receptor binding
- receptor tyrosine kinase binding