PTTG1IP Gene Summary [Human]
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | PTTG1IP |
| Official Name | PTTG1 interacting protein [Source:HGNC Symbol;Acc:HGNC:13524] |
| Ensembl ID | ENSG00000183255 |
| Bio databases IDs | |
| Aliases | PTTG1 interacting protein |
| Synonyms | 1810010L20Rik, C21orf1, C21orf3, Locuslink 108705, PBF, pituitary tumor-transforming 1 interacting protein, pituitary tumour-transforming 1 interacting protein, PTTG1 interacting protein, PTTG1IP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTTG1IP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear localization sequence
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- pervasive developmental disorder
- Down syndrome
- gallstone
- multinodular goiter
- ankylosing spondylitis
role in cell
- expression in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTTG1IP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- protein import into nucleus
- positive regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding