Pttg1ip Gene Summary [Rat]
Predicted to enable p53 binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and positive regulation of protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTTG1IP (PTTG1 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pttg1ip |
| Official Name | PTTG1 interacting protein [Source:RGD Symbol;Acc:1305983] |
| Ensembl ID | ENSRNOG00000001223 |
| Bio databases IDs | |
| Aliases | PTTG1 interacting protein |
| Synonyms | 1810010L20Rik, C21orf1, C21orf3, Locuslink 108705, PBF, pituitary tumor-transforming 1 interacting protein, pituitary tumour-transforming 1 interacting protein, PTTG1 interacting protein, PTTG1IP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pttg1ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear localization sequence
- p53 binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- pervasive developmental disorder
- Down syndrome
- gallstone
- multinodular goiter
- ankylosing spondylitis
role in cell
- expression in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pttg1ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- protein import into nucleus
- positive regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding