ZNRF3 Gene Summary [Human]
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in cellular protein metabolic process and negative regulation of Wnt signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNRF3 |
| Official Name | zinc and ring finger 3 [Source:HGNC Symbol;Acc:HGNC:18126] |
| Ensembl ID | ENSG00000183579 |
| Bio databases IDs | |
| Aliases | zinc and ring finger 3 |
| Synonyms | BK747E2.3, Gm1167, LOC100364268, RNF203, zinc and ring finger 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNRF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- frizzled binding
- ubiquitin protein ligase activity
- ectodomain
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- dishevelled interacting region
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- ZNRF-3 Ectodomain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- hyperplasia
- pancreatic epithelial cancer
- schizophrenia
- prostatic carcinoma
- prostate cancer
role in cell
- expression in
- proliferation
- apoptosis
- cisplatin resistance
- commitment
- temozolomide resistance
- removal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNRF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- limb development
- stem cell proliferation
- negative regulation of non-canonical Wnt receptor signaling pathway
- regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- Wnt receptor signaling pathway
- Wnt receptor catabolic process
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- frizzled binding
- protein binding
- metal ion binding