MKI67 Gene Summary [Human]
Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MKI67 |
| Official Name | marker of proliferation Ki-67 [Source:HGNC Symbol;Acc:HGNC:7107] |
| Ensembl ID | ENSG00000148773 |
| Bio databases IDs | |
| Aliases | marker of proliferation Ki-67, protein phosphatase 1, regulatory subunit 105, Molecular Immunology Borstel antibody 1 |
| Synonyms | antigen identified by monoclonal antibody Ki 67, D630048A14Rik, Ki-67, KIA, marker of proliferation Ki-67, MIB-, MIB-1, MIKI67A, MKI67A, PPP1R105 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MKI67 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inner membrane component of T3SS, cytoplasmic domain
- KI67R (NUC007) repeat
- protein phosphatase 1 binding
- FHA domain
- protein binding activity, bridging
- Forkhead associated domain
- protein binding
- forkhead associated (FHA) domain superfamily
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- adrenal cortex carcinoma
- adrenocortical carcinoma
- placental trophoblastic neoplasm
- placental cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- quantity
- apoptosis
- proliferation
- cell cycle progression
- segregation
- mitosis
- frequency
- proliferation by
- damage in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- basal compartment
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleoli
- nuclear bodies
- centromeres
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MKI67 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of chromosome segregation
- cell proliferation
- regulation of mitosis
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- nuclear body
- membrane
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- RNA binding
- protein binding