Tbl3 Gene Summary [Mouse]
Predicted to enable U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of 90S preribosome and small-subunit processome. Predicted to be active in nucleolus. Is expressed in genitourinary system. Orthologous to human TBL3 (transducin beta like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbl3 |
| Official Name | transducin (beta)-like 3 [Source:MGI Symbol;Acc:MGI:2384863] |
| Ensembl ID | ENSMUSG00000040688 |
| Bio databases IDs | |
| Aliases | transducin (beta)-like 3 |
| Synonyms | 9430070M15Rik, SAZD, transducin (beta)-like 3, transducin beta like 3, transducin (β)-like 3, transducin β like 3, UTP13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Utp13 specific WD40 associated domain
- WD40 repeats
- peptidase
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- 90S preribosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- U3 snoRNA binding