ADAP2 Gene Summary [Human]
The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ADAP2 |
| Official Name | ArfGAP with dual PH domains 2 [Source:HGNC Symbol;Acc:HGNC:16487] |
| Ensembl ID | ENSG00000184060 |
| Bio databases IDs | |
| Aliases | ArfGAP with dual PH domains 2 |
| Synonyms | ArfGAP with dual PH domains 2, CENTA2, cent-b, HSA272195 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Putative GTP-ase activating proteins for the small GTPase, ARF
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- phosphatidylinositol binding
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrial envelope
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- metal ion binding
- GTPase activator activity
- phosphatidylinositol-3,4-bisphosphate binding
- inositol 1,3,4,5 tetrakisphosphate binding
- protein binding, bridging