KCTD10 Gene Summary [Human]
The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | KCTD10 |
| Official Name | potassium channel tetramerization domain containing 10 [Source:HGNC Symbol;Acc:HGNC:23236] |
| Ensembl ID | ENSG00000110906 |
| Bio databases IDs | |
| Aliases | potassium channel tetramerization domain containing 10 |
| Synonyms | AW536343, BTBD28, hBACURD3, mBACURD3, MSTP028, potassium channel tetramerisation domain containing 10, potassium channel tetramerization domain containing 10, ULRO61 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCTD10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ubiquitin-protein transferase activity
- protein binding
- identical protein binding
- ion channel
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- age-related hearing loss
- growth failure
- neuroticism
- hearing loss
regulates
role in cell
- expression in
- endothelial barrier integrity
- ubiquitination in
- degradation in
- TAK-901 resistance
- dipeptide repeat protein sensitivity
- CSN5i-3 sensitivity
- pladienolide B sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCTD10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of Rho protein signal transduction
- protein homooligomerization
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- Cul3-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- Notch binding