RNF34 Gene Summary [Human]
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | RNF34 |
| Official Name | ring finger protein 34 [Source:HGNC Symbol;Acc:HGNC:17297] |
| Ensembl ID | ENSG00000170633 |
| Bio databases IDs | |
| Aliases | ring finger protein 34 |
| Synonyms | CARP1, hRFI, MGC7670, Momo, RFI, RIF, RIFF, ring finger protein 34 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- ubiquitin protein ligase binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- p53 binding
- protein binding
- phosphatidylinositol binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- organelle
- presynaptic regions
- Nucleus
- Plasma Membrane
- nucleoplasm
- nuclear bodies
- nuclear speckles
- synapse
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- apoptotic process
- regulation of oxygen metabolic process
- cellular response to cold
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nuclear speck
- cytosol
- endomembrane system
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- metal ion binding