FFAR3 Gene Summary [Human]
Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FFAR3 |
| Official Name | free fatty acid receptor 3 [Source:HGNC Symbol;Acc:HGNC:4499] |
| Ensembl ID | ENSG00000185897 |
| Bio databases IDs | |
| Aliases | free fatty acid receptor 3 |
| Synonyms | Ffa3, FFA3R, free fatty acid receptor 3, Gm478, GPR41, GPR42 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FFAR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the FFAR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gαi Signaling
- Molecular Mechanisms of Cancer
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypotension
- Huntington disease
- fasting hypoglycemia
role in cell
- expression in
- quantity
- activation
- response by
- shortening
- steroidogenesis in
- innervation
- action potential
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FFAR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- regulation of peptide hormone secretion
- negative regulation of blood pressure
- regulation of norepinephrine secretion
- regulation of hormone biosynthetic process
- mucosal immune response
- regulation of insulin receptor signaling pathway
- positive regulation of cytokine production involved in immune response
- inflammatory response
- cellular response to fatty acid
- positive regulation of acute inflammatory response to non-antigenic stimulus
- positive regulation of chemokine production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- lipid binding