LPAR5 Gene Summary [Human]
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | LPAR5 |
| Official Name | lysophosphatidic acid receptor 5 [Source:HGNC Symbol;Acc:HGNC:13307] |
| Ensembl ID | ENSG00000184574 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 5 |
| Synonyms | Gm1072, GPC92, GPR92, GPR93, KPG 010, LPA5, lysophosphatidic acid receptor 5, RGD1562580 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPAR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the LPAR5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- neuropathic pain
- thyroid carcinoma
- epithelial thyroid cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- restless legs syndrome
role in cell
- migration
- apoptosis
- expression in
- growth
- transcription in
- proliferation
- quantity
- signaling in
- cisplatin sensitivity
- leakage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPAR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- behavioral response to pain
- positive regulation of CREB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity