PARPBP Gene Summary [Human]
Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PARPBP |
| Official Name | PARP1 binding protein [Source:HGNC Symbol;Acc:HGNC:26074] |
| Ensembl ID | ENSG00000185480 |
| Bio databases IDs | |
| Aliases | PARP1 binding protein, PARP-1 binding protein |
| Synonyms | 4930547N16Rik, AROM, C12orf48, FLJ20641, PARI, PARP1 binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARPBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA-interacting protein box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colon epithelial cancer
- colorectal cancer
- hyperplasia
- herniation
- fibrosis
- prostatic carcinoma
- prostate cancer
- colon carcinoma
role in cell
- hydroxyurea sensitivity
- activity
- chromosomal aberration in
- origin firing in
- homologous recombination in
- mitomycin C sensitivity
- sister chromatid exchange in
- aneuploidy
- genomic stability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARPBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of double-strand break repair via homologous recombination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding