POLR3D Gene Summary [Human]
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR3D |
| Official Name | RNA polymerase III subunit D [Source:HGNC Symbol;Acc:HGNC:1080] |
| Ensembl ID | ENSG00000168495 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit D |
| Synonyms | 2810426M17Rik, BN51, BN51T, C53, polymerase (RNA) III (DNA directed) polypeptide D, RNA polymerase III subunit D, RPC4, RPC53, TSBN51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA-directed RNA polymerase
- chromatin binding
- RNA polymerase III RPC4
Pathways
Biological processes and signaling networks where the POLR3D gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- chromatin binding