RGS9BP Gene Summary [Human]
The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | RGS9BP |
| Official Name | regulator of G protein signaling 9 binding protein [Source:HGNC Symbol;Acc:HGNC:30304] |
| Ensembl ID | ENSG00000186326 |
| Bio databases IDs | |
| Aliases | regulator of G protein signaling 9 binding protein |
| Synonyms | PERRS, PERRS2, R9AP, regulator of G protein signaling 9 binding protein, regulator of G-protein signalling 9 binding protein, RGD1561747, RGS9, Rgs9-1bp |
| Species | Human, Homo sapiens |
| Orthologies |
Pathways
Biological processes and signaling networks where the RGS9BP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrite tip
- Cytoplasm
- cellular membrane
- nerve ending
- photoreceptor outer segments
- postsynaptic density
- rod outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RGS9BP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of light stimulus involved in visual perception
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- neuron projection