TNFRSF18 Gene Summary [Human]
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF18 |
| Official Name | TNF receptor superfamily member 18 [Source:HGNC Symbol;Acc:HGNC:11914] |
| Ensembl ID | ENSG00000186891 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 18 |
| Synonyms | AITR, CD357, ENERGEN, GITR, GITR-D, TNF receptor superfamily member 18, TR11, Tumor necrosis factor receptor superfamily, member 18, tumour necrosis factor receptor superfamily, member 18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- tumor necrosis factor receptor
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- neoplasia
- organismal death
- breast cancer
- psoriatic arthritis
- invasive ductal breast cancer
- diabetic nephropathy
- infiltrating ductal breast carcinoma
- hyperplasia
- Crohn disease
role in cell
- expression in
- cell death
- apoptosis
- proliferation
- survival
- cellular infiltration
- quantity
- cellular infiltration by
- phosphorylation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- basal compartment
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of leukocyte migration
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor-activated receptor activity