HSPA14 Gene Summary [Human]
Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HSPA14 |
| Official Name | heat shock protein family A (Hsp70) member 14 [Source:HGNC Symbol;Acc:HGNC:29526] |
| Ensembl ID | ENSG00000187522 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 14 |
| Synonyms | heat shock protein 14, heat shock protein family A (Hsp70) member 14, HSP70-4, HSP70L1, hsr.1, LOC100503996, LOC100861945, MSANTD7, NST-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MreB/Mbl protein
- peptidase
- protein binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone mediated protein folding requiring cofactor
- 'de novo' cotranslational protein folding
- protein refolding
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- ribosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- heat shock protein binding
- protein binding involved in protein folding
- protein binding