TCEA1 Gene Summary [Human]
Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TCEA1 |
| Official Name | transcription elongation factor A1 [Source:HGNC Symbol;Acc:HGNC:11612] |
| Ensembl ID | ENSG00000187735 |
| Bio databases IDs | |
| Aliases | transcription elongation factor A1, transcription factor IIS |
| Synonyms | GTF2S, S-II, TCEA, TF2S, TFIIS, transcription elongation factor A1, transcription elongation factor A (SII) 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCEA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Transcription factor S-II (TFIIS), central domain
- TFIIS helical bundle-like domain
- TFIIS_I
- Zn-ribbon
- protein binding
- transcription elongation factor S-II
- Transcription factor S-II M domain
Pathways
Biological processes and signaling networks where the TCEA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- metastatic colorectal cancer
- hypoplasia
- anemia
- amyotrophic lateral sclerosis
regulates
- RNA polymerase II
- DNA endogenous promoter
- DNA promoter
- RNAPOL2/ERCC6
- POLE
role in cell
- differentiation
- abnormal morphology
- transcription-coupled nucleotide-excision repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCEA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding