PABIR1 Gene Summary [Human]
Enables protein serine/threonine phosphatase inhibitor activity. Involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PABIR1 |
| Official Name | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 [Source:HGNC Symbol;Acc:HGNC:23490] |
| Ensembl ID | ENSG00000187866 |
| Bio databases IDs | |
| Aliases | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 |
| Synonyms | 2410124L17Rik, 2900009I07Rik, C9orf42, FAM122A, Gm9849, PP2A A alpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1, PP2A A α (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1, RGD1310316 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PABIR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- type 1 serine/threonine specific protein phosphatase inhibitor
- protein phosphatase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PABIR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding