PPP3R1
PPP3R1 Gene Summary
Enables cyclosporin A binding activity; phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPP3R1 |
| Official Name | protein phosphatase 3 regulatory subunit B, alpha [Source:HGNC Symbol;Acc:HGNC:9317] |
| Ensembl ID | ENSG00000221823 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3 regulatory subunit B, alpha, calcineurin B, type I (19kDa), protein phosphatase 2B regulatory subunit B alpha |
| Synonyms | Calcineurin b,Calcineurin B1,CALNB1,CaNB1,CNB,CNB1,CnB short,MCIP1,Pp2b Beta1,PP2B-R,PP2B REGULATORY A subunit alpha1 (BRAIN-SPECIFIC),Pp2b Regulatory B Subunit Beta 1 (Brain-Specific),Pp2b Regulatory B Subunit β 1 (Brain-Specific),protein phosphatase 3 regulatory subunit B, alpha,protein phosphatase 3, regulatory subunit B, alpha,protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I),protein phosphatase 3 regulatory subunit B, α,protein phosphatase 3, regulatory subunit B, α,protein phosphatase 3, regulatory subunit B, α isoform (calcineurin B, type I) |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain pair
- cyclosporin A binding
- enzyme binding
- EFh
- protein domain specific binding
- protein binding
- EFh_MICU
- EFh_PI-PLC
- The penta-EF hand (PEF) family
- EF-hand domain
- protein phosphatase
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase
- phosphatase binding
Pathways
Biological processes and signaling networks where the PPP3R1 gene plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- B Cell Receptor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- STXBP4
- YWHAG
- MAP3K5
- BRI3BP
- HSBP1
- STX7
- TMEM200A
- HSPA8
- GPM6A
- PDHB
disease
- Waldenström macroglobulinemia
- mantle cell lymphoma
- refractory chronic lymphocytic leukemia
- COVID-19
- epithelial cancer
- diabetes mellitus
- acute graft-vs-host disease
- breast cancer
- advanced colon adenocarcinoma
- psoriasis
regulated by
- beta-estradiol
- FSH
- NFATC3
- NFATC2
- SLC9A1
- NFATC4
- mast cells
- tacrolimus
- cisplatin
- LH
regulates
- insulin
- Scd1
- Scd2
- 14-3-3
- PPP3R1
- Gucy2g
- PPP3CA
- ABCA13
- BAD
- BAG3
role in cell
- number
- activation in
- proliferation
- apoptosis
- hypertrophy
- quantity
- degranulation
- development
- differentiation
- switching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
- apical cytoplasm
- basal cytoplasm
- apical membrane
- basal membrane
- nucleoplasm
- synapse
- sarcolemma
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PPP3R1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- heart development
- myelination in peripheral nervous system
- lung epithelial cell differentiation
- patterning of blood vessels
- protein import into nucleus
- protein dephosphorylation
- positive regulation of calcineurin-NFAT signaling cascade
- epithelial to mesenchymal transition
- positive regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- calcineurin complex
- protein serine/threonine phosphatase complex
- sarcolemma
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphatase binding
- cyclosporin A binding
- calmodulin binding
- protein domain specific binding
- protein binding
- calcium-dependent protein serine/threonine phosphatase activity
- calcium ion binding
- calcium-dependent protein serine/threonine phosphatase regulator activity