FYB2 Gene Summary [Human]
Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FYB2 |
| Official Name | FYN binding protein 2 [Source:HGNC Symbol;Acc:HGNC:27295] |
| Ensembl ID | ENSG00000187889 |
| Bio databases IDs | |
| Aliases | FYN binding protein 2, activation-dependent, raft-recruited ADAP-like phosphoprotein |
| Synonyms | 1700024P16Rik, AABR07049499.1, ARAP, C1orf168, FYN binding protein 2, Gm620, LOC103690060, LOC242594, RGD1564074 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FYB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- disorder of esophagus
- idiopathic scoliosis
- schizophrenia
- endometrial carcinoma
- epithelial endometrial cancer
- cleft lip
role in cell
- tyrosine phosphorylation in
- adhesion
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- immunological synapses
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FYB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- T cell receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- membrane raft
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding