SRSF10 Gene Summary [Human]
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | SRSF10 |
| Official Name | serine and arginine rich splicing factor 10 [Source:HGNC Symbol;Acc:HGNC:16713] |
| Ensembl ID | ENSG00000188529 |
| Bio databases IDs | |
| Aliases | serine and arginine rich splicing factor 10, splicing factor, arginine/serine-rich 13, SR splicing factor 10, protein phosphatase 1, regulatory subunit 149 |
| Synonyms | FUSIP1, FUSIP2, LOC100505793, LOC100996657, LOC642558, LOC727922, NSSR, NSSR1, NSSR2, PPP1R149, serine and arginine-rich splicing factor 10, SFRS13, SFRS13A, SRp38, SRrp40, Srsf13a, TASR, TASR1, TASR2, TLS-associated serine-arginine |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRSF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- arginine-serine-rich domain 3
- arginine-serine-rich domain 1
- RNA recognition motif
- protein binding
- arginine-serine-rich domain 2
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- neoplasia
- ventricular septal defect
- growth failure
- atrial septal defect
- complete atrioventricular septal defect
role in cell
- expression in
- colony formation by
- sphere formation by
- splicing by
- transport in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- perikaryon
- dendrites
- axon terminals
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRSF10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing, via transesterification reactions
- negative regulation of nuclear mRNA splicing, via spliceosome
- cytoplasmic transport
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA splice site selection
- regulation of transcription, DNA-dependent
- nuclear mRNA splicing, via spliceosome
- assembly of spliceosomal tri-snRNP
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- cytoplasm
- nuclear speck
- cytosol
- neuronal cell body
- axon terminus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- unfolded protein binding
- RS domain binding