MTF1 Gene Summary [Human]
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MTF1 |
| Official Name | metal regulatory transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:7428] |
| Ensembl ID | ENSG00000188786 |
| Bio databases IDs | |
| Aliases | metal regulatory transcription factor 1 |
| Synonyms | LOC100909856, metal-regulatory transcription factor 1, metal response element binding transcription factor 1, Thyls, ZRF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nuclear export signal
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- acidic domain
- proline rich domain
- C2H2-type zinc ribbon
- DNA binding
- double-stranded DNA binding
- Zinc-finger double domain
- serine threonine rich domain
- zinc finger domain
- transcription factor activity
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the MTF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- rheumatoid arthritis
- systemic lupus erythematosus
- lung cancer
- organismal death
- survival
- systemic sclerosis
- hypothyroidism
- urothelial bladder carcinoma
- transitional cell bladder cancer
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- sensitivity
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- central nervous system development
- cellular response to zinc ion
- transcription, DNA-dependent
- response to metal ion
- response to cadmium ion
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- histone acetyltransferase binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription