ALKBH2 Gene Summary [Human]
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ALKBH2 |
| Official Name | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase [Source:HGNC Symbol;Acc:HGNC:32487] |
| Ensembl ID | ENSG00000189046 |
| Bio databases IDs | |
| Aliases | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
| Synonyms | 9530023G02, ABH2, alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase, alkB homolog 2, α-ketoglutarate-dependent dioxygenase, mABH2, RGD1306377 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALKBH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- 2-oxoglutarate:oxygen oxidoreductase
- demethylase activity
- enzyme
- protein binding
- ribosomal DNA (rDNA) binding protein
- hydrolase
- 2OG-Fe(II) oxygenase superfamily
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALKBH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ferrous iron binding
- rDNA binding
- cytosine C-5 DNA demethylase activity
- oxidative DNA demethylase activity