Alkbh2 Gene Summary [Mouse]
Enables broad specificity oxidative DNA demethylase activity and cytosine C-5 DNA demethylase activity. Involved in DNA alkylation repair. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human ALKBH2 (alkB homolog 2, alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alkbh2 |
| Official Name | alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase [Source:MGI Symbol;Acc:MGI:2141032] |
| Ensembl ID | ENSMUSG00000044339 |
| Bio databases IDs | |
| Aliases | alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase |
| Synonyms | 9530023G02, ABH2, alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase, alkB homolog 2, α-ketoglutarate-dependent dioxygenase, mABH2, RGD1306377 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alkbh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- 2-oxoglutarate:oxygen oxidoreductase
- demethylase activity
- enzyme
- protein binding
- ribosomal DNA (rDNA) binding protein
- hydrolase
- 2OG-Fe(II) oxygenase superfamily
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alkbh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ferrous iron binding
- rDNA binding
- cytosine C-5 DNA demethylase activity
- oxidative DNA demethylase activity