IL1RAPL2
IL1RAPL2 Gene Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL1RAPL2 |
| Official Name | interleukin 1 receptor accessory protein like 2 [Source:HGNC Symbol;Acc:HGNC:5997] |
| Ensembl ID | ENSG00000189108 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor accessory protein like 2 |
| Synonyms | IL-1R9,interleukin 1 receptor accessory protein-like 2,RGD1561761,TIGIRR,TIGIRR-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- TIR domain
- interleukin-1 receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL1RAPL2 gene plays a role, providing insight into its function and relevance in health or disease.
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EGFR
- H2BC21
- miR-146a-5p (and other miRNAs w/seed GAGAACU)
disease
regulated by
- beta-estradiol
- RXRA
- RXRB
- topotecan
regulates
role in cell
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL1RAPL2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- central nervous system development
- cytokine-mediated signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- interleukin-1, Type II, blocking receptor activity
- interleukin-1 receptor activity