Il1rapl2 Gene Summary [Mouse]
Predicted to enable NAD+ nucleosidase activity, cyclic ADP-ribose generating and interleukin-1, type II, blocking receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be active in cell surface; glutamatergic synapse; and plasma membrane. Is expressed in brain and spinal cord floor plate. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1rapl2 |
| Official Name | interleukin 1 receptor accessory protein-like 2 [Source:MGI Symbol;Acc:MGI:1913106] |
| Ensembl ID | ENSMUSG00000059203 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor accessory protein-like 2 |
| Synonyms | IL-1R9, interleukin 1 receptor accessory protein-like 2, RGD1561761, TIGIRR, TIGIRR-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il1rapl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- TIR domain
- interleukin-1 receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il1rapl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il1rapl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- cytokine-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- interleukin-1, Type II, blocking receptor activity
- interleukin-1 receptor activity