MMP23B
MMP23B Gene Summary
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MMP23B |
| Official Name | matrix metallopeptidase 23B [Source:HGNC Symbol;Acc:HGNC:7171] |
| Ensembl ID | ENSG00000189409 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 23B, matrix metalloproteinase 22, femalysin, matrix metalloproteinase in the female reproductive tract |
| Synonyms | CA-MMP,matrix metallopeptidase 23,matrix metallopeptidase 23B,MIFR,MIFR-1,MMP22,Mmp23,MMP23A,Mmp23bB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Matrixin
- ZnMc
- ShK domain-like
- immunoglobulin domain
- peptidase
- Zinc-dependent metalloprotease
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the MMP23B gene plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SRPK2
- MMP23B
disease
- preeclampsia
- androgenic alopecia
- hypertrophic scarring
- endometriosis
regulated by
- TP53
- CTNNB1
- lipopolysaccharide
- Enterotoxin
- HRAS
- BRAF
- PTEN
- NKX3-1
- forskolin
- 8-bromo-cAMP
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear membrane fraction
- membrane fraction
- cell periphery
- perinuclear region
- ER-to-Golgi intermediate compartment
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MMP23B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- proteolysis
- extracellular matrix organization
- collagen catabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular matrix
MOLECULAR FUNCTION
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity
- metallopeptidase activity