NFKBIZ Gene Summary [Human]
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NFKBIZ |
| Official Name | NFKB inhibitor zeta [Source:HGNC Symbol;Acc:HGNC:29805] |
| Ensembl ID | ENSG00000144802 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor zeta, IL-1 inducible nuclear ankyrin-repeat protein, NF-kappa-B inhibitor zeta |
| Synonyms | I-kappa-B-zeta, IkappaB-ζ, IKBZ, IKB zeta, IKB ζ, INAP, I-κ-B-ζ, MAIL, NFKB inhibitor zeta, NFKB inhibitor ζ, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, ζ, RGD1310834 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFKBIZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- nucleic acid binding
- double-stranded DNA binding
- Ankyrin repeats (3 copies)
- transcription cofactor
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
Pathways
Biological processes and signaling networks where the NFKBIZ gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- experimental autoimmune encephalomyelitis
- COVID-19
- chronic kidney disease
- epithelial cancer
- inflammatory bowel disease
- colorectal cancer
- ulcerative colitis
- Alzheimer disease
- acanthosis
role in cell
- growth
- differentiation
- expression in
- proliferation
- production in
- apoptosis
- induction in
- binding in
- cell death
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic ribonucleoprotein granule
- nuclear foci
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFKBIZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spleen development
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- execution phase of apoptosis
- establishment of skin barrier
- T cell mediated immunity
- chromatin remodeling
- plasma cell differentiation
- cytokine-mediated signaling pathway
- keratinocyte activation
- T cell receptor signaling pathway
- isotype switching
- mRNA transcription from RNA polymerase II promoter
- response to cisplatin
- keratinocyte proliferation
- defense response to Gram-negative bacterium
- positive regulation of inflammatory response
- B cell proliferation
- T-helper 1 cell differentiation
- toll-like receptor signaling pathway
- cellular response to transforming growth factor beta stimulus
- chronic inflammatory response
- keratinocyte differentiation
- cellular response to lipopolysaccharide
- homeostasis of number of cells within a tissue
- response to folic acid
- regulation of gene expression
- positive regulation of T-helper 17 cell differentiation
- DNA-dependent transcriptional preinitiation complex assembly
- T-helper 17 cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- POU domain binding