SULT1A1 Gene Summary [Human]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | SULT1A1 |
| Official Name | sulfotransferase family 1A member 1 [Source:HGNC Symbol;Acc:HGNC:11453] |
| Ensembl ID | ENSG00000196502 |
| Bio databases IDs | |
| Aliases | sulfotransferase family 1A member 1 |
| Synonyms | aryl sulfotranserase, aryl sulphotranserase, ASTIV, HAST1/HAST2, mSTp1, Mx-ST, Phenol Sulfotransferase, Phenol sulphotransferase, P-PST, P-PST 1, PST, PST-1, ST1A1, ST1A3, St1a4, Stm, STP, STP1, sulfotransferase family 1A member 1, sulfotransferase family 1A, phenol-preferring, member 1, sulphotransferase family 1A member 1, sulphotransferase family 1A, phenol-preferring, member 1, Sult1a3, ts-PST, TSPST1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SULT1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- nucleotide binding
- steroid sulfotransferase
- enzyme
- protein binding
- flavonol 3-sulfotransferase
- identical protein binding
- amine sulfotransferase
- binding protein
- Sulfotransferase domain
- aryl sulfotransferase
- 3'-phosphoadenosine 5'-phosphosulfate binding
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the SULT1A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- endometrial cancer
- obesity
- Crohn disease
- allergic rhinitis
- doxorubicin induced cardiotoxicity
- inflammatory bowel disease
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- progressive familial intrahepatic cholestasis type 1
regulates
- dopamine
- 4-nitrophenol
- epicatechin
- 8-hydroxy-6-formylindolo[3,2-b]carbazole
- CTNNB1
- xenobiotic
- bisphenol A
- flavonoid
- 2-hydroxyestradiol
- estrone
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SULT1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amine metabolic process
- estrogen metabolic process
- xenobiotic metabolic process
- ethanol catabolic process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- sulfation
- catecholamine metabolic process
- flavonoid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- flavonol 3-sulfotransferase activity
- steroid sulfotransferase activity
- aryl sulfotransferase activity
- sulfotransferase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding