Sult1a1 Gene Summary [Mouse]
Enables nucleotide binding activity and sulfotransferase activity. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland and nervous system. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A3 (sulfotransferase family 1A member 3); and SULT1A4 (sulfotransferase family 1A member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sult1a1 |
| Official Name | sulfotransferase family 1A, phenol-preferring, member 1 [Source:MGI Symbol;Acc:MGI:102896] |
| Ensembl ID | ENSMUSG00000030711 |
| Bio databases IDs | |
| Aliases | sulfotransferase family 1A, phenol-preferring, member 1 |
| Synonyms | aryl sulfotranserase, aryl sulphotranserase, ASTIV, HAST1/HAST2, mSTp1, Mx-ST, Phenol Sulfotransferase, Phenol sulphotransferase, P-PST, P-PST 1, PST, PST-1, ST1A1, ST1A3, St1a4, Stm, STP, STP1, sulfotransferase family 1A member 1, sulfotransferase family 1A, phenol-preferring, member 1, sulphotransferase family 1A member 1, sulphotransferase family 1A, phenol-preferring, member 1, Sult1a3, ts-PST, TSPST1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sult1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- nucleotide binding
- steroid sulfotransferase
- enzyme
- protein binding
- flavonol 3-sulfotransferase
- identical protein binding
- amine sulfotransferase
- binding protein
- Sulfotransferase domain
- aryl sulfotransferase
- 3'-phosphoadenosine 5'-phosphosulfate binding
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Sult1a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- endometrial cancer
- obesity
- Crohn disease
- allergic rhinitis
- doxorubicin induced cardiotoxicity
- inflammatory bowel disease
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- progressive familial intrahepatic cholestasis type 1
regulates
- dopamine
- 4-nitrophenol
- epicatechin
- 8-hydroxy-6-formylindolo[3,2-b]carbazole
- CTNNB1
- xenobiotic
- bisphenol A
- flavonoid
- 2-hydroxyestradiol
- estrone
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sult1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amine metabolic process
- estrogen metabolic process
- xenobiotic metabolic process
- ethanol catabolic process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- sulfation
- catecholamine metabolic process
- flavonoid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- flavonol 3-sulfotransferase activity
- steroid sulfotransferase activity
- aryl sulfotransferase activity
- sulfotransferase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding