SLC22A4 Gene Summary [Human]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC22A4 |
| Official Name | solute carrier family 22 member 4 [Source:HGNC Symbol;Acc:HGNC:10968] |
| Ensembl ID | ENSG00000197208 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 4 |
| Synonyms | DFNB60, ETTh, OCTN1, solute carrier family 22 member 4, solute carrier family 22 (organic cation transporter), member 4, UT2H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation porter
- benzoate transport
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- Multidrug resistance protein
- phosphate:H+ symporter
- protein binding
- betaine transporter
- PDZ-domain binding
- organic cation transporter
- Sugar (and other) transporter
- acetylcholine transporter
- carnitine transporter
- cation transport protein
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- inflammatory bowel disease
- organismal death
- coronary artery disease
- dermatitis
- breast carcinoma
- rheumatoid arthritis
- myocardial infarction
- susceptibility to rheumatoid arthritis
- Crohn disease
regulates
- triacylglycerol
- carnitine
- L-carnitine
- ergothioneine
- quaternary ammonium compound
- amino acids
- tetraethylammonium
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Mitochondria
- apical membrane
- basal membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- quaternary ammonium group transport
- neurotransmitter transport
- xenobiotic transport
- triglyceride metabolic process
- carnitine transport
- carnitine metabolic process
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- mitochondrial membrane
- mitochondrion
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- quaternary ammonium group transmembrane transporter activity
- betaine transmembrane transporter activity
- PDZ domain binding
- symporter activity
- amino acid transmembrane transporter activity
- acetylcholine transmembrane transporter activity
- secondary active organic cation transmembrane transporter activity
- carnitine transporter activity