PHF20 Gene Summary [Human]
Predicted to enable DNA binding activity and metal ion binding activity. Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PHF20 |
| Official Name | PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098] |
| Ensembl ID | ENSG00000025293 |
| Bio databases IDs | |
| Aliases | PHD finger protein 20, tudor domain containing 20A |
| Synonyms | 6820402O20Rik, C20orf104, GLEA2, HCA58, NZF, PHD finger protein 20, RGD1305020, TDRD20A, TZP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHF20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3776)
- PHD zinc finger
- transcription regulator
- DNA repair protein Crb2 Tudor domain
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- PHD finger superfamily
- protein binding
- Tudor domain superfamily
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- migraines
- non-melanoma skin cancer
- osteoarthritis
- cardioembolic stroke
- systemic juvenile idiopathic arthritis
- breast carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHF20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytosol
- NSL complex
- MLL1 complex
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding