PHF2 Gene Summary [Human]
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PHF2 |
| Official Name | PHD finger protein 2 [Source:HGNC Symbol;Acc:HGNC:8920] |
| Ensembl ID | ENSG00000197724 |
| Bio databases IDs | |
| Aliases | PHD finger protein 2, jumonji C domain-containing histone demethylase 1E, centromere protein 35 |
| Synonyms | CENP-35, GRC5, JHDM1E, KDM7C, PHD finger protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- Jumonji helical domain
- histone binding
- transcription co-activator
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- iron ion binding
- enzyme
- protein binding
- RmlC-like cupin superfamily
- zinc ion binding
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of chromatin silencing at rDNA
- positive regulation of gene expression, epigenetic
- protein demethylation
- positive regulation of transcription, DNA-dependent
- liver development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- kinetochore
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone demethylase activity (H4-K20 specific)
- transcription cofactor activity
- transcription coactivator activity
- iron ion binding
- methylated histone residue binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity