Phf2 Gene Summary [Mouse]
Enables histone H4K20 demethylase activity. Involved in transcription initiation-coupled chromatin remodeling. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human PHF2 (PHD finger protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf2 |
| Official Name | PHD finger protein 2 [Source:MGI Symbol;Acc:MGI:1338034] |
| Ensembl ID | ENSMUSG00000038025 |
| Bio databases IDs | |
| Aliases | PHD finger protein 2 |
| Synonyms | CENP-35, GRC5, JHDM1E, KDM7C, PHD finger protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- Jumonji helical domain
- histone binding
- transcription co-activator
- 2-oxoglutarate:oxygen oxidoreductase
- protein binding activity, bridging
- iron ion binding
- enzyme
- protein binding
- RmlC-like cupin superfamily
- zinc ion binding
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of chromatin silencing at rDNA
- positive regulation of gene expression, epigenetic
- protein demethylation
- positive regulation of transcription, DNA-dependent
- liver development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- kinetochore
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone demethylase activity (H4-K20 specific)
- transcription cofactor activity
- transcription coactivator activity
- iron ion binding
- methylated histone residue binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity