Hmgn5 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within chromatin organization; glutathione metabolic process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; gut gland; and hemolymphoid system gland. Orthologous to human HMGN5 (high mobility group nucleosome binding domain 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgn5 |
| Official Name | high-mobility group nucleosome binding domain 5 [Source:MGI Symbol;Acc:MGI:1355295] |
| Ensembl ID | ENSMUSG00000031245 |
| Bio databases IDs | |
| Aliases | high-mobility group nucleosome binding domain 5 |
| Synonyms | GARP45, high-mobility group nucleosome binding domain 5, NBP-45, NSBP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmgn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- chromatin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- pulmonary emphysema
role in cell
- apoptosis
- binding in
- binding
- proliferation
- number
- frequency
- decompaction
- decompaction in
- organization
- abnormal number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmgn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- nucleosomal DNA binding
- chromatin binding