WDHD1 Gene Summary [Human]
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | WDHD1 |
| Official Name | WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170] |
| Ensembl ID | ENSG00000198554 |
| Bio databases IDs | |
| Aliases | WD repeat and HMG-box DNA binding protein 1, CTF4, chromosome transmission fidelity factor 4 homolog (S. cerevisiae) |
| Synonyms | A630092E18, AND-1, CHTF4, CTF4, D630024B06RIK, WD repeat and HMG-box DNA binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDHD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- Minichromosome loss protein, Mcl1, middle region
- WD domain, G-beta repeat
- enzyme binding
- chromatin binding
- WD40
- protein binding
- SepB domain
- DNA binding
- RNA binding
- Anaphase-promoting complex subunit 4 WD40 domain
- WD-like repeat
- WD40 repeats
- high mobility group
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chordoma
- bone cancer
- colorectal carcinomagenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Parkinson disease
- cleft lip
- colorectal carcinoma
role in cell
- binding in
- ubiquitination in
- degradation in
- number
- organization
- misalignment
- association
- misalignment in
- stabilization in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WDHD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA-dependent DNA replication
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear replication fork
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding