DTL Gene Summary [Human]
Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DTL |
| Official Name | denticleless E3 ubiquitin protein ligase homolog [Source:HGNC Symbol;Acc:HGNC:30288] |
| Ensembl ID | ENSG00000143476 |
| Bio databases IDs | |
| Aliases | denticleless E3 ubiquitin protein ligase homolog, RA regulated nuclear matrix associated protein, DDB1 and CUL4 associated factor 2 |
| Synonyms | 2810047L02RIK, 5730564G15Rik, CDT2, DCAF2, denticleless E3 ubiquitin protein ligase, denticleless E3 ubiquitin protein ligase homolog, L2DTL, LOC100909566, NONMMUG002837, RAMP, RGD1310439 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DTL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- ubiquitin-protein transferase activity
- WD domain, G-beta repeat
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- breast cancer
- lung adenocarcinoma
- liver cancer
- cleft lip
- organismal death
- lung squamous cell carcinoma
- squamous cell lung cancer
- small cell lung cancer
role in cell
- growth
- accumulation in
- cell death
- expression in
- degradation in
- phosphorylation in
- proliferation
- apoptosis
- number
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- contractile rings
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DTL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- protein polyubiquitination
- DNA replication
- positive regulation of protein catabolic process
- response to UV
- response to DNA damage stimulus
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- regulation of cell cycle
- translesion synthesis
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nuclear membrane
- Cul4A-RING ubiquitin ligase complex
- Cul4B-RING ubiquitin ligase complex
- cytosol
- chromosome
- nucleolus
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- protein binding, bridging