STK39 Gene Summary [Human]
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | STK39 |
| Official Name | serine/threonine kinase 39 [Source:HGNC Symbol;Acc:HGNC:17717] |
| Ensembl ID | ENSG00000198648 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 39, STE20/SPS1 homolog (yeast) |
| Synonyms | DCHT, Gm50618, PASK, RF005, Rnl5, serine threonine kinase 39, serine/threonine kinase 39, SPAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK39 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- channel regulator
- Protein kinase (unclassified specificity)
- protein kinase binding
- regulatory domain
- Protein tyrosine and serine/threonine kinase
- caspase cleavage site
- nuclear localization sequence
- protein binding
- Protein kinase domain
- alanine-proline rich region
- potassium channel inhibitor
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- ion channel binding
- Oxidative-stress-responsive kinase 1 C-terminal domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypotension
- diabetic nephropathy
- essential hypertension
- COVID-19
- insulin-dependent diabetes mellitus
- metastasis
- advanced cancer
- cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- replication in
- activation
- degradation in
- migration
- differentiation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cellular membrane
- cell cortex
- cytosol
- apical membrane
- basolateral membrane
- nucleoplasm
- nodes of Ranvier
- perikaryon
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK39 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- positive regulation of potassium ion transport
- response to dietary excess
- protein phosphorylation
- macrophage activation
- cell volume homeostasis
- inflammatory response
- cellular hypotonic response
- cellular hyperosmotic response
- negative regulation of sodium ion transmembrane transporter activity
- cellular chloride ion homeostasis
- intracellular signal transduction
- chemokine (C-X-C motif) ligand 12 signaling pathway
- signal transduction
- negative regulation of pancreatic juice secretion
- regulation of blood pressure
- positive regulation of p38MAPK cascade
- renal sodium ion absorption
- positive regulation of T cell chemotaxis
- regulation of inflammatory response
- sodium ion transmembrane transport
- positive regulation of ion transmembrane transporter activity
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cell cortex
- cell body
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- kinase activity