RELT Gene Summary [Human]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RELT |
| Official Name | RELT TNF receptor [Source:HGNC Symbol;Acc:HGNC:13764] |
| Ensembl ID | ENSG00000054967 |
| Bio databases IDs | |
| Aliases | RELT TNF receptor, receptor expressed in lymphoid tissues |
| Synonyms | AI3C, E430021K24Rik, RELT TNF receptor, RELT, TNF receptor, RELT tumor necrosis factor receptor, RELT tumour necrosis factor receptor, TNFRSF19L, TRLT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RELT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
- Tumour necrosis factor receptor superfamily member 19
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amelogenesis imperfecta type IIIC
- amelogenesis imperfecta
- Ullrich congenital muscular dystrophy
regulates
- NFkB (complex)
role in cell
- proliferation
- apoptosis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RELT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- amelogenesis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding