DAB2 Gene Summary [Human]
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | DAB2 |
| Official Name | DAB adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:2662] |
| Ensembl ID | ENSG00000153071 |
| Bio databases IDs | |
| Aliases | DAB adaptor protein 2 |
| Synonyms | 5730435J12Rik, D15Wsu122e, D630005B22Rik, DAB adaptor protein 2, disabled 2, mitogen-responsive phosphoprotein, DOC-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin VI binding domain
- SMAD binding
- FxDxF motif
- cargo receptor activity
- protein binding activity, bridging
- RGD motif
- clathrin binding
- low-density lipoprotein receptor binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- proline rich domain
- phosphatidylinositol binding
- binding protein
- RXXsL motif
- phosphatidylinositol-4,5-bisphosphate binding
- integrin binding
- NPF motif
- DPF domain
Pathways
Biological processes and signaling networks where the DAB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- hypercholesterolemia
- epithelial ovarian cancer
- chronic kidney disease
- autosomal dominant Emery-Dreifuss muscular dystrophy
- pancreatic carcinoma
- pancreatic epithelial cancer
- systemic lupus erythematosus
- peripheral arterial disease
role in cell
- cell death
- proliferation
- expression in
- migration
- aggregation
- apoptosis
- phosphorylation in
- activation in
- binding in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fibrillar center
- annular gap junction vesicle
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- granules
- cytosol
- apical membrane
- lysosome membrane
- alpha granules
- endocytotic vesicle
- apical vesicles
- gap junctions
- brush border
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of endocytosis
- protein transport
- transforming growth factor beta receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein binding
- negative regulation of androgen receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- integrin-mediated signaling pathway
- negative regulation of neuron projection development
- negative regulation of cell growth
- clathrin coat assembly
- apoptotic process
- Wnt receptor signaling pathway
- positive regulation of SMAD protein import into nucleus
- positive regulation of aldosterone biosynthetic process
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of clathrin-mediated endocytosis
- response to steroid hormone stimulus
- positive regulation of substrate adhesion-dependent cell spreading
- receptor-mediated endocytosis
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of apoptotic process
- negative regulation of ERK1 and ERK2 cascade
- cellular response to epidermal growth factor stimulus
- negative regulation of epithelial cell proliferation
- positive regulation of protein phosphorylation
- positive regulation of early endosome to late endosome transport
- leading edge cell differentiation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of aldosterone secretion
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- coated pit
- intracellular membrane-bounded organelle
- cytosol
- clathrin-coated vesicle
- fibrillar center
- lysosomal membrane
- plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- low-density lipoprotein particle receptor binding
- protein binding
- SMAD binding
- cargo receptor activity
- clathrin adaptor activity