MIR31 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR31 |
| Official Name | microRNA 31 [Source:HGNC Symbol;Acc:HGNC:31630] |
| Ensembl ID | ENSG00000199177 |
| Bio databases IDs | |
| Aliases | microRNA 31 |
| Synonyms | hsa-miR-31, microRNA 31, microRNA 3554, Mir31a, Mir31b, Mir3554, MIRN31, mmu-miR-31, rno-miR-31, rno-mir-31a, rno-mir-31b, rno-mir-3554 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- mRNA binding
- translation repressor
- protein binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR31 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- squamous cell cancer
- hyperglycemia
- nonalcoholic fatty liver disease
- papillary thyroid carcinoma
- papillary thyroid cancer
- nonobstructive azoospermia
role in cell
- phosphorylation in
- expression in
- activation in
- invasion by
- apoptosis
- proliferation
- production in
- migration
- growth
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- microvesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- negative regulation of inflammatory response
- cellular response to tumor necrosis factor
- positive regulation of cell migration involved in sprouting angiogenesis
- negative regulation of amyloid precursor protein biosynthetic process
- positive regulation of blood vessel endothelial cell migration
- negative regulation of cell migration
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA 3'-UTR binding