FGF10 Gene Summary [Human]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF10 |
| Official Name | fibroblast growth factor 10 [Source:HGNC Symbol;Acc:HGNC:3666] |
| Ensembl ID | ENSG00000070193 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 10 |
| Synonyms | AEY17, Fgf5a, fibroblast growth factor 10, Gsfaey17, LADD3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- chemoattractant
- protein binding
- fibroblast growth factor receptor binding
- heparin binding
- growth factor
Pathways
Biological processes and signaling networks where the FGF10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- rheumatoid arthritis
- prostate cancer
- Alzheimer disease
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
- non-small cell lung cancer
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- binding in
- degradation in
- differentiation
- quantity
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGF10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Ras protein signal transduction
- branching morphogenesis of a tube
- regulation of smoothened signaling pathway
- urothelial cell proliferation
- epithelial cell proliferation
- positive regulation of lymphocyte proliferation
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- mesonephros development
- positive regulation of epithelial cell proliferation
- positive regulation of urothelial cell proliferation
- male genitalia morphogenesis
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- female genitalia morphogenesis
- embryonic camera-type eye development
- semicircular canal fusion
- Type II pneumocyte differentiation
- prostatic bud formation
- vascular endothelial growth factor receptor signaling pathway
- embryonic genitalia morphogenesis
- metanephros morphogenesis
- negative regulation of stem cell proliferation
- mesenchymal cell differentiation involved in lung development
- positive regulation of stem cell proliferation
- hair follicle morphogenesis
- submandibular salivary gland formation
- positive regulation of cell proliferation
- spleen development
- lung epithelium development
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of transcription from RNA polymerase II promoter
- lung proximal/distal axis specification
- epithelial cell proliferation involved in salivary gland morphogenesis
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
- regulation of saliva secretion
- thymus development
- branch elongation involved in salivary gland morphogenesis
- fibroblast proliferation
- smooth muscle cell differentiation
- angiogenesis
- white fat cell proliferation
- positive regulation of fibroblast proliferation
- stem cell proliferation
- somatic stem cell maintenance
- positive regulation of keratinocyte migration
- positive regulation of epithelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- mesenchymal-epithelial cell signaling involved in lung development
- positive regulation of ATPase activity
- radial glial cell differentiation
- positive regulation of MAPK cascade
- determination of left/right symmetry
- thyroid gland development
- metanephros development
- otic vesicle formation
- positive regulation of protein phosphorylation
- endothelial cell proliferation
- response to lipopolysaccharide
- positive regulation of endothelial cell proliferation
- protein localization at cell surface
- positive chemotaxis
- muscle cell fate commitment
- bud elongation involved in lung branching
- fibroblast growth factor receptor signaling pathway
- embryonic digestive tract morphogenesis
- bud outgrowth involved in lung branching
- white fat cell differentiation
- regulation of activin receptor signaling pathway
- wound healing
- lacrimal gland development
- Wnt receptor signaling pathway
- positive regulation of hair follicle cell proliferation
- positive regulation of DNA repair
- lung saccule development
- embryonic pattern specification
- positive regulation of canonical Wnt receptor signaling pathway
- bronchiole morphogenesis
- pituitary gland development
- organ morphogenesis
- tear secretion
- negative regulation of epithelial cell differentiation
- positive regulation of gene expression
- positive regulation of white fat cell proliferation
- organ induction
- response to estradiol stimulus
- regulation of cell migration
- secretion by lung epithelial cell involved in lung growth
- odontogenesis of dentin-containing tooth
- salivary gland development
- positive regulation of Notch signaling pathway
- positive regulation of keratinocyte proliferation
- Harderian gland development
- induction of positive chemotaxis
- pancreas development
- keratinocyte proliferation
- positive regulation of G1/S transition of mitotic cell cycle
- limb bud formation
- positive regulation of epithelial cell proliferation involved in wound healing
- mammary gland bud formation
- tissue regeneration
- ERK1 and ERK2 cascade
- establishment of mitotic spindle orientation
- blood vessel remodeling
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- chemoattractant activity
- heparin binding
- type 2 fibroblast growth factor receptor binding
- fibroblast growth factor receptor binding