MAN2B2 Gene Summary [Human]
Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MAN2B2 |
| Official Name | mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623] |
| Ensembl ID | ENSG00000013288 |
| Bio databases IDs | |
| Aliases | mannosidase alpha class 2B member 2, core-specific lysosomal alpha-1,6-Mannosidase, Epididymis-specific alpha-mannosidase |
| Synonyms | Ab2-450, alpha-MANNOSIDASE (EPIDIDYMIS-SPECIFIC), CORE-SPECIFIC alpha-1,6-MANNOSIDASE, CORE-SPECIFIC α-1,6-MANNOSIDASE, EpMAN, KIAA0935, mannosidase 2, alpha B2, mannosidase 2, α B2, mannosidase alpha class 2B member 2, mannosidase, alpha, class 2B, member 2, mannosidase α class 2B member 2, mannosidase, α, class 2B, member 2, mKIAA0935, α-MANNOSIDASE (EPIDIDYMIS-SPECIFIC) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAN2B2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 38 N-terminal domain
- Alpha mannosidase middle domain
- alpha-mannosidase
- GH38-57_N_LamB_YdjC_SF
- Alpha mannosidase, middle domain
- Glycosyl hydrolases family 38 C-terminal domain
- mannan endo-1,6-beta-mannosidase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- lysosome
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAN2B2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mannose metabolic process
- oligosaccharide catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-mannosidase activity
- protein binding
- metal ion binding
- carbohydrate binding